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A collection of data can statistically be assessed to generate information on its distribution. This distribution reveals the potentially affected fraction of species at a given exposure concentration. One could assume that the data of interest are representative of a log- ; normal distribution. If all endpoints for all species had been listed, the distribution could be fitted on the data resulting in a threshold value at a chosen level e.g. 5th percentile ; with a chosen confidence level e.g. 95% ; Aldenberg and Jaworska, 2000 ; . This technique is widely applied in standard setting and risk assessment Van Beelen and Doelman, 1997; Posthuma et al., 2002 ; . This Species Sensitivity Distribution SSD ; approach will be examined with the assumption that all substances that are present in the dataset have a similar distribution of effects. However, the dataset in Table 1 presumably does not show all available test results.
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References 1. Tequin gatifloxacin ; [product monograph]. Montreal: Bristol-Myers Squibb Canada Co.; 2002. 2. Levaquin levofloxacin ; [product monograph]. Toronto: Janssen-Ortho Inc.; 2004. 3. Floxin ofloxacin ; [product monograph]. Toronto: Janssen-Ortho Inc.; 2004. 4. Cipro ciprofloxacin ; [product monograph]. Toronto: Bayer Inc.; 2004. 5. Avelox moxifloxacin ; [product monograph]. Toronto: Bayer Inc.; 2004. 6. Noroxih norfloxacin ; [product monograph]. Kirkland QC ; : Merck Frosst Canada Inc; 1997. 7. Marchbanks CR. Drug-drug interaction with fluoroquinolones. Pharmacotherapy, 13 2 ; : 23S28S 1993 ; . 8. Ellis, R.J., Mayo, M.S., Bodensteiner, D.M. Ciprofloxacin-warfarin coagulopathy: a case series. American Journal of Hematology, 63 1 ; : 2831 2000 ; . 9. Jones, C.B., Fugate, S.E. Levofloxacin and warfarin interaction. Annals of Pharmacotherapy, 36 10 ; : 1554 1557 2002 ; . 10. Pea, F., Furlanut, M. Pharmacokinetic aspects of treating infections in the intensive care unit: focus on drug interactions. Clinical Pharmacokinetics, 40 11 ; : 833868 2001 and nortriptyline.
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Boehringer-ingelheim , felix octavio martinez alcala 1 from the university of sã o paulo, sã o paulo city, brazil , jorge antonio aldrete velasco 1 from the university of sã o paulo, sã o paulo city, brazil and roberto jose risco cortes 1 from the university of sã o paulo, sã o paulo city, brazil 1 from the university of sã o paulo, sã o paulo city, brazil ae: adverse event; alat: alanine aminotransferase; asat: aspartate aminotransferase; cox: cyclooxygenase; gi: gastrointestinal; nsaid: nonsteroidal antiinflammatory drug; d. Search plans for coverage. Request drug, tier exception. Page 19 of 24, for example, norfloxacino.
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