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Those patients who had CK Table 4. Alanine Transaminase Cross-tabulations tests ordered; most of the published incidence rates Maximum ALT Before Conversion report CK elevations as a percentage of the total numNormal Mild Increase Marked Increase ber of patients on statin 0-40 U L ; 41-120 U L ; 121 U L ; Total prescriptions. The slightly improved Maximum Normal 19 067 1763 ALT After 0-40 U L ; 92.8% ; 50.6% ; 53.9% ; lipid results we observed at Conversion equipotent doses may Mild 1391 1681 56 reflect external patient facIncrease 6.8% ; 48.3% ; 33.5% ; tors associated with the 41-120 U L ; conversion. Patients may 87 38 21 Marked have become more compliIncrease 0.4% ; 1.1% ; 12.6% ; ant with their new regimen 121 U L ; due to increased contact with providers. Patients also 20 545 3482 Total knew that laboratory followup was a necessary part of ALT indicates alanine transaminase. the conversion, and the fact that outreach efforts were made to those patients who failed to get laboratory tests done could also have affect- may still be an advantage, especially for patients with tiered or generic-only drug coverage plans. ed the results. The results of our study revealed that just 56.4% and A limitation of this study is that it relied on electronic data capture and did not include direct patient con- 72.2% of patients had reached the identified LDL-C tact or chart reviews by the investigators. This can lead goals of 100 and 130 mg dL in the secondary-preto misclassification errors, especially when separating vention and primary-prevention groups, respectively. patients into primary-prevention and secondary-pre- Although this did represent an increase from preconvention categories based on registry data, or when eval- version values, significant opportunity for improveuating postconversion dose-adjustment groupings. One ment remains. Although the original conversion anomalous finding was that patients with effective post- program actively recommended consideration of conversion dosage reductions also achieved lower post- dosage adjustment in patients with baseline LDL-C valconversion LDL-C values. Information not captured ues at 10% above goal, it was not designed with an electronically but available to the provider may explain aggressive titration feature. Ongoing conversion prothese results. For example, providers may have decided grams now recommend a dosage or medication adjustto reduce the dose based on clinical circumstances out- ment in patients whenever the baseline LDL-C value is greater than goal. side of LDL-C results and CK or ALT values. Another limitation to this study is that clinical outcomes were not measured; lipid laboratory results were CONCLUSION used as surrogate effectiveness markers and the primary This study of more than 33 000 patients demonend point for this analysis. The follow-up period also was strates that appropriately selected patients can be safeshort and variable, ranging from 3 to 15 months. Therefore, we were unable to assess patients' persistence ly and effectively converted from branded simvastatin long-term adherence ; with their new lovastatin regimen. Zodor ; to generic lovastatin. The relative cost of statins within managed care organizations is highly dependent on contracting, such REFERENCES that a cost analysis would have limited generalizability. 1. Randomized trial of cholesterol lowering in 444 patients with coronary heart Although generic lovastatin is the most cost-effective disease: the Scandinavian Simvastatin Survival Study 4S ; . Lancet. statin for mild to moderate LDL-C reductions within KP, 1994; 344 8934 ; : 1383-1389. 2. Shepherd J, Cobbee SM, Ford I, et al. Prevention of coronary heart disease with this may not be the case in other organizations or out- pravastatin in men with hypercholesterolemia. West of Scotland Coronary side of the managed care environment. From the Prevention Study Group. N Engl J Med. 1995; 333: 1301-1307. Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary patient's perspective, the availability of a generic statin events after myocardial infarction in patients with average cholesterol levels.
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Zocor and diabetesReferences: 1. Package insert information: Mevacor - June, 2002; Zoc9r - Sept, 2003; Crestor - Aug, 2003; Lescol - Aug, 2002; and Pravachol - March, 2003. 2. Jones PH, Davidson MH, Stein EA, et al. Comparison of the Efficacy and Safety of Rosuvastatin versus Atorvastatin, Simvastatin, and Pravastatin Across Doses STELLAR * Trial ; . AmJCardiol. 2003 Jul 15; 92 2 ; : 152-60. 3. Downs JR, Clearfield M, Weis S, et al. Primary Prevention of Acute Coronary Events with Lovastatin in Men and Women with Average Cholesterol Levels: Results of AFCAPS TexCAPS. JAMA 1998; 279: 1615-1622. Sever RS, Dahlof B, et al. Prevention of Coronary and Stroke Events in Hypertensive Patients.Lancet 2003: Apr 5; 361 9364 ; : 1149-58 5. Athyroos V, Papageorgiou AA, et al. GREACE.Curr Med Res Opin 2002; 18 4 ; : 220-228. 6. Scandinavian Simvastatin Survival Study Group. Randomised Trial of Cholesterol Lowering in 4444 Patients with Coronary Heart Disease: the Scandinavian Simvastatin Survival Study 4S ; . Lancet 1994; 344: 1383-1389. Heart Protection Study Collaborative Group. MRC BHF Heart Protection Study of Cholesterol Lowering with Simvastatin in 20, 536 High-Risk Individuals: a Randomised Placebo-Controlled Trial. Lancet 2002: 360 9326 ; : 7-22. 8. Serruys PW, de Feyter P, Macaya C, et al for the Lescol Intervention Prevention Study LIPS ; Investigators. Fluvastatin for Prevention of Cardiac Events Following Successful First Percutaneous Coronary Intervention: a Randomized Controlled . Trial. JAMA 2002; 287 24 ; : 3215-22. 9. Shepherd J, Cobbe SM, Ford I, et al. Prevention of Coronary Heart Disease in Men with Hypercholesterolemia. N Engl J Med 1995; 333: 1301-1307. Sacks FM, Pfeffer MA, Moye LA et al. The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels. N Engl J Med 1996; 335: 1001-1009. Long-Term Intervention with Pravastatin in Ischaemic Disease LIPID ; Study Group. Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels. N Engl J Med. 1998; 339: 1349-1357. Anon. ACC AHA NHLBI Clinical Advisory on the Use and Safety of Statins. Circulation 2002; 106: 1024-1028. Nissen SE, Nicholls SJ, Sipahi I, et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA. 2006; 295: 15561565. Executive Summary of the Third Report of the National Cholesterol Education Program NCEP ; Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Adult Treatment Panel III ; , JAMA 2001; 285: 2486-2497. To process patents that extend the innovator's protection after the expiration of the original patent. In the second case, pharmaceutical firms have been accused of modifying successful products marketed by competitors in expanding markets as a way to steal profits. These follow-on products are for this reason often denoted as me-too drugs. The market for statins is a case in point. Statins are cholesterol-lowering drugs that appeared in the 1990s. Starting from Lovastatin, several firms have introduced competing varieties of the compound like simvastatin Zocog ; , atorvastatin Lipitor ; , pravastatin pravachol ; , fluvastatin Lescol ; or rosuvastatin Crestor ; . These products are claimed to be close substitutes, and arguably they involve a lower risk and lower investment than the development of more innovative products.4 We aim to understand why firms in this market tend to target their research to these small improvements. Starting with Nordhaus 1969 ; , existing literature on innovation has commonly argued that to the extent that firms do not internalize all the surplus of the innovations they generate, underinvestment is likely to arise. The existence of patents is seen as a way to address this inefficiency and classical papers such as Gilbert and Shapiro 1990 ; and Klemperer 1990 ; have studied the trade-offs of longer versus wider patents. Recent papers, such as Scotchmer 1999 ; , have shown that patents are also efficient tools to relate the value of the invention to the social reward it generates. In this paper, we argue that in obtaining the optimal level of innovation an additional margin is important. As the previous examples illustrate, firms typically choose the size of the innovation they pursue, and for this reason, underinvestment or overinvestment ; will be a function of how close is the contribution for each size of innovation they might achieve to the social welfare they generate. Misallocation of resources will occur in markets where the signals originating from the demand for the good are dampened in a systematic way. The results we obtain are related to the particular structure of the demand for pharmaceutical products, compared to other markets where innovation is important. Patients often do not pay nor they choose the medications they purchase, as they are prescribed by their and zyrtec. JOURNAL OF INTERNAL MEDICINE Official Publication of API-UP Chapter ; It is a three monthly publication. Each issue has a symposium on a particular field in Medicine besides other very useful matter. Symposia being published in 1996 and 1997 are: 1. Ischemic Heart Disease 2. Hypertension 3. Cerebrovascular Disease 4. Critical Care Medicine 5. Headache 6. Tuberculosis 7. Imaging Techniques 8. Dermatology. Zocor generic nameWhat is the difference between tricor and zocor
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Crestor and zocor lower the amount of total cholesterol in the bloodstream, including ldl or bad cholesterol, and triglycerides carried in the bloodstream.
Home articles health topics diseases & conditions tests & procedures drugs & supplements symptoms site map quick links cholesterol triglycerides high cholesterol cholesterol levels low cholesterol diet lowering cholesterol low cholesterol food lipitor crestor zocor vytorin zetia lipitor side effects tricor uses among the licensed uses for tricor are reducing cholesterol levels in people with high cholesterol and triglyceride levels in people with high triglycerides and achromycin.
Read all this leaflet carefully before you start taking this medicine. - Keep this leaflet. You may need to read it again. - If you have further questions, please ask your doctor or your pharmacist. - This medicine has been prescribed for you personally and you should not pass it on the others. It may harm them, even if their symptoms are the same as yours. In this leaflet: 1. What ZOCOR 10 mg film-coated tablets is and what it is used for 2. Before you take ZOCOR 10 mg film-coated tablets 3. How to take ZOCOR 10 mg film-coated tablets 4. Possible side effects 5. Storing ZOCOR 10 mg film-coated tablets ZOCOR 10 mg film-coated tablets simvastatin ; The active substance is simvastatin. Each tablet contains 10 mg of simvastatin. The other ingredients excipients ; are: butylated hydroxyanisole E-320 ; , ascorbic acid, citric acid monohydrate, microcrystalline cellulose, without gluten pregelatinized maize starch, lactose, magnesium stearate, hydroxypropyl methylcellulose, hydroxypropylcellulose, titanium dioxide E-171 ; , talc, yellow ferric oxide E-172 ; , red ferric oxide E-172 ; . License holder: MERCK SHARP & DOHME DE ESPAA, S.A. C Josefa Valcrcel, 38 28027 MADRID Manufacturing responsible: FROSST IBRICA, S.A. Va Complutense, 140. 28805 Alcal de Henares Madrid. When does zocor go generic in usa
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